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2013•MoleculesOpen access

Two New Sphingolipids from the Leaves of Piper betle L.

Duo‐Zhi Chen, Huabin Xiong, Kai Tian, Junming Guo, Xiang‐Zhong Huang, Zhi‐Yong Jiang

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Abstract

Two new sphingolipids, pipercerebrosides A (1) and B (2), were isolated from the leaves of Piper betle L. Their structures, including absolute configurations, were determined by spectroscopic analysis and chemical degradation. These two compounds did not show significant cytotoxic activity against the cancer cell lines K562 and HL-60 in a MTT assay.

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Two new sphingolipids, pipercerebrosides A (1) and B (2), were isolated from the leaves of Piper betle L. Their structures, including absolute configurations, were determined by spectroscopic analysis and chemical degradation. These two compounds did not show significant cytotoxic activity against the cancer cell lines K562 and HL-60 in a MTT assay.

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Available abstract

Two new sphingolipids, pipercerebrosides A (1) and B (2), were isolated from the leaves of Piper betle L. Their structures, including absolute configurations, were determined by spectroscopic analysis and chemical degradation. These two compounds did not show significant cytotoxic activity against the cancer cell lines K562 and HL-60 in a MTT assay.

Key concepts: Piper, Sphingolipid, MTT assay, Chemistry, Cytotoxicity, Cytotoxic T cell, Traditional medicine, Cancer cell lines

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