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Use of 100-Hertz Tetanus as an Index of Recovery from Pancuronium-Induced Non-depolarizing Neuromuscular Blockade

Aaron F. Kopman, Ralph H. Epstein, Michael H. Flashburg

Open publisher page 22 citations

Abstract

During recovery from non-depolarizing neuromuscular blockade the evoked response to train-of-four (TOF), 100-HZ tetanus (T100) and 50-HZ tetanus (T50) was measured in 10 patients. When the TOF fade ratio exceeded 0.70, tetanic tension to T50 was well sustained. However, even at TOF ratios as high as 0.88 a 2-second tetanic response to T100 showed marked fade. T100 stimulation appears to be too sensitive a test to residual curarization for routine clinical use. Fade on T100 may be quite apparent at a time when the use of additional neuromuscular antagonists are not indicated and may be counterproductive.

About this research paper

What this paper is about

During recovery from non-depolarizing neuromuscular blockade the evoked response to train-of-four (TOF), 100-HZ tetanus (T100) and 50-HZ tetanus (T50) was measured in 10 patients. When the TOF fade ratio exceeded 0.70, tetanic tension to T50 was well sustained. However, even at TOF ratios as high as 0.88 a 2-second tetanic response to T100 showed marked fade. T100 stimulation appears to be too sensitive a test to residual curarization for routine clinical use. Fade on T100 may be quite apparent at a time when the use of additional neuromuscular antagonists are not indicated and may be counterproductive.

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OpenAlex reports 22 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

During recovery from non-depolarizing neuromuscular blockade the evoked response to train-of-four (TOF), 100-HZ tetanus (T100) and 50-HZ tetanus (T50) was measured in 10 patients. When the TOF fade ratio exceeded 0.70, tetanic tension to T50 was well sustained. However, even at TOF ratios as high as 0.88 a 2-second tetanic response to T100 showed marked fade. T100 stimulation appears to be too sensitive a test to residual curarization for routine clinical use. Fade on T100 may be quite apparent at a time when the use of additional neuromuscular antagonists are not indicated and may be counterproductive.

Key concepts: Neuromuscular monitoring, Fade, Neuromuscular Blockade, Medicine, Tetanus, Neuromuscular Blocking Agents, Anesthesia, Neuromuscular junction

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Use of 100-Hertz Tetanus as an Index of Recovery from Pancuronium-Induced Non-depolarizing Neuromuscular Blockade — Research Paper | ScholarLens