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EFFECTS OF CYCLOHEXIMIDE AND ACTINOMYCIN D ON PRODUCTION OF ACIDIC NUCLEAR PROTEINS IN HUMAN LYMPHOCYTES ACTIVATED BY PHYTOHEMAGGLUTININ

Satoshi Dekio

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Abstract

Previous studies have implicated a role for acidic nuclear proteins in the PHA stimulated activation of human lymphocytes. This study examines the mechanism of synthesis of these proteins. Cycloheximide inhibited their production, while Actinomycin D did not. It is suggested that synthesis proceeds by translation of dormant messenger RNA rather than of newly synthesized messenger RNA.

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What this paper is about

Previous studies have implicated a role for acidic nuclear proteins in the PHA stimulated activation of human lymphocytes. This study examines the mechanism of synthesis of these proteins. Cycloheximide inhibited their production, while Actinomycin D did not. It is suggested that synthesis proceeds by translation of dormant messenger RNA rather than of newly synthesized messenger RNA.

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Available abstract

Previous studies have implicated a role for acidic nuclear proteins in the PHA stimulated activation of human lymphocytes. This study examines the mechanism of synthesis of these proteins. Cycloheximide inhibited their production, while Actinomycin D did not. It is suggested that synthesis proceeds by translation of dormant messenger RNA rather than of newly synthesized messenger RNA.

Key concepts: Cycloheximide, Protein biosynthesis, Messenger RNA, Translation (biology), Dactinomycin, RNA, Cell biology, Chemistry

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EFFECTS OF CYCLOHEXIMIDE AND ACTINOMYCIN D ON PRODUCTION OF ACIDIC NUCLEAR PROTEINS IN HUMAN LYMPHOCYTES ACTIVATED BY PHYTOHEMAGGLUTININ — Research Paper | ScholarLens