2012•Dalton TransactionsRequires access

Zeolitic imidazolate framework-8 as efficient pH-sensitive drug delivery vehicle

Chunyi Sun, Chao Qin, Xinlong Wang, Guang‐Sheng Yang, Kui‐Zhan Shao, Ya‐Qian Lan, Zhong‐Min Su, Peng Huang, Chungang Wang, En‐Bo Wang

Open publisher page 715 citations

Abstract

Zeolitic Imidazolate Framework-8 (ZIF-8), for the first time for ZIFs, exhibits a remarkable capacity for the anticancer drug 5-fluorouracil (5-FU), around 660 mg of 5-FU/g of ZIF-8, and presents a pH-triggered controlled drug release property. These prove ZIF-8 to be a valuable candidate for delivery of anticancer agents and reveal its potential applications in the treatment of cancer.

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Key concepts: Zeolitic imidazolate framework, Imidazolate, Drug delivery, Drug, Anticancer drug, Chemistry, Nanotechnology, Combinatorial chemistry