1996•Biomedical ReviewsOpen access
Dual effect of sympathetic hyperfunction on blood vessels in spontaneously hypertensive and stroke-prone spontaneously hypertensive rats
Mari Kondo, Tatyana Tenkova, Takashi Fujiwara
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Abstract
The sympathetic nervous system has been considered to be hyperactive from the very beginning after birth in spontaneously hypertensive and stroke-prone spontaneously hypertensive rats. This is a primary factor for the development and maintenance of hypertension via structural and functional alterations of the arteries and the heart. It is also described that the sympathetic hyperfunction probably play a protective role in necrosis of vascular smooth muscle cells in spontaneously hypertensive and stroke-prone spontaneously hypertensive rats. Biomedical Reviews 1996; 6: 57-68.
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