Effects of Various Co-Surfactants and Oils on Microemulsion Formation in Decylglucoside System

Decylglucoside is a non-ionic, non-toxic, biodegradable surfactant. This work aimed to establish composition where stable microemulsions could form using hydrophilic lipophilic deviation (HLD) concept to optimise the formulations. Scanning for suitable ratios of surfactant and co-surfactant was carried out by altering the surfactant/co-surfactant (S/CoS) ratios with two co-surfactants and seven different oils in order to find the optimum formulations. From the optimal S/CoS ratios, pseudo-ternary phase diagrams by dilution were subsequently performed, leading to obtain microemulsion zones. The zones of microemulsions could be observed in the systems composed of decylglucoside/sorbitan monooleate/isopropyl myristate/water at the 0.10/0.90 and 0.20/0.80 S/CoS ratios and decylglucoside/sorbitan monooleate /isopropyl palmitate/water at the 0.10/0.90, 0.15/0.85 and 0.20/0.80 S/CoS ratios. The microemulsion zones of two systems were similar and found at high surfactant concentrations. However, the studied decylglucoside microemulsion systems were interesting in drug and cosmetic applications because it consisted of non-ionic surfactant and co-surfactant, resulting low toxic products.