2006•Journal of Asian Natural Products ResearchRequires access
O-methyl nakafuran-8 lactone, a new sesquiterpenoid from a hainan marine sponge Dysidea sp.
Ziying Shao, Jiang Li, Chung-Ja Sim, J.-Y. Li, Z.-y. Li, Fajun Nan, Y.-W. Guo
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Abstract
A new sesquiterpenoid, O-methyl nakafuran-8 lactone (1) has been isolated from a Hainan sponge Dysidea sp. and the structure of the new compound proposed by spectral data, was confirmed by X-ray diffraction analysis. The complete 1H- and 13C-NMR assignments were made on the basis of detailed 2D NMR spectral analysis. Compound 1 showed strong inhibitory bioactivity against PTP1B with IC50 value of 1.58 microM.