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Neural fold abnormalities induced in newt embryos by a carcinogen

Panagiotis A. Tsonis

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Abstract

The effects of a carcinogen, N-methyl-N′-nitro-N-nitrosoguanidine (MNNG), on newt embryonic development were studied. When embryos are treated with MNNG before the blastula stage, abnormal development occurs. The most prominent effect is that the hinder region of the egg–embryo (vegetal pole) does not participate in the development; thus, only one hemisphere (animal pole) of the egg develops. This phenomenon is evident at the gastrula stage and becomes even more apparent during the neurula stage.

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What this paper is about

The effects of a carcinogen, N-methyl-N′-nitro-N-nitrosoguanidine (MNNG), on newt embryonic development were studied. When embryos are treated with MNNG before the blastula stage, abnormal development occurs. The most prominent effect is that the hinder region of the egg–embryo (vegetal pole) does not participate in the development; thus, only one hemisphere (animal pole) of the egg develops. This phenomenon is evident at the gastrula stage and becomes even more apparent during the neurula stage.

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Available abstract

The effects of a carcinogen, N-methyl-N′-nitro-N-nitrosoguanidine (MNNG), on newt embryonic development were studied. When embryos are treated with MNNG before the blastula stage, abnormal development occurs. The most prominent effect is that the hinder region of the egg–embryo (vegetal pole) does not participate in the development; thus, only one hemisphere (animal pole) of the egg develops. This phenomenon is evident at the gastrula stage and becomes even more apparent during the neurula stage.

Key concepts: Blastula, Biology, Neurula, Gastrulation, Embryo, Embryogenesis, Carcinogen, Conceptus

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