A comparison of five commonly prescribed antidepressants with particular reference to their behavioural toxicity

Abstract Five antidepressant drugs (amitriptyline, dothiepin, lofepramine, fluoxetine and paroxetine) were examined for their effects on psychological function and skilled performance using a meta‐analytical technique for the combination of separate studies. Furthermore, the drugs were placed and contrasted upon dimensions of efficacy, side‐effects, safety in overdose and price in an attempt to formalize and provide a practical example of the considerations which should underlie the selection and use of such compounds. In both these analyses the profile of lofepramine, fluoxetine and paroxetine were found to be favourable compared to those of amitriptyline and dothiepin, suggesting that the prescription of older tricyclic compounds should be the exception rather than the rule in the pharmacotherapy of depression.