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2006•BloodOpen access

AKTion on mantle cell lymphoma

Michael R. Gold

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Abstract

Patients with mantle cell lymphoma (MCL) generally have a poor prognosis.Rudelius and colleagues now show that the PI 3-kinase/Akt prosurvival signaling pathway is constitutively activated in the more aggressive blastoid form of MCL and that inhibitory drugs targeting this pathway promote the apoptosis of MCL cells, raising the possibility of new treatments for blastoid MCL.

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What this paper is about

Patients with mantle cell lymphoma (MCL) generally have a poor prognosis.Rudelius and colleagues now show that the PI 3-kinase/Akt prosurvival signaling pathway is constitutively activated in the more aggressive blastoid form of MCL and that inhibitory drugs targeting this pathway promote the apoptosis of MCL cells, raising the possibility of new treatments for blastoid MCL.

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Available abstract

Patients with mantle cell lymphoma (MCL) generally have a poor prognosis.Rudelius and colleagues now show that the PI 3-kinase/Akt prosurvival signaling pathway is constitutively activated in the more aggressive blastoid form of MCL and that inhibitory drugs targeting this pathway promote the apoptosis of MCL cells, raising the possibility of new treatments for blastoid MCL.

Key concepts: Blastoid, Mantle cell lymphoma, Cancer research, Lymphoma, Protein kinase B, Medicine, Signal transduction, Biology

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