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1989•British Journal of DermatologyRequires access

Failure of terfenadine in relieving the pruritus of atopic dermatitis

J. Berth‐Jones, R.A.C. GRAHAM-BROWN

Open publisher page 96 citations

Abstract

We report the results of a double-blind, placebo-controlled, cross-over study of terfenadine 120 mg twice daily for pruritus in atopic dermatitis. Twenty-eight subjects with chronic atopic dermatitis received both terfenadine 120 mg b.d. and placebo each for a period of 1 week. Response was recorded by the subjects using visual analogue scales for severity of pruritus twice daily for the last 4 days of each treatment phase. There was no benefit from terfenadine.

About this research paper

What this paper is about

We report the results of a double-blind, placebo-controlled, cross-over study of terfenadine 120 mg twice daily for pruritus in atopic dermatitis. Twenty-eight subjects with chronic atopic dermatitis received both terfenadine 120 mg b.d. and placebo each for a period of 1 week. Response was recorded by the subjects using visual analogue scales for severity of pruritus twice daily for the last 4 days of each treatment phase. There was no benefit from terfenadine.

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OpenAlex reports 96 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

We report the results of a double-blind, placebo-controlled, cross-over study of terfenadine 120 mg twice daily for pruritus in atopic dermatitis. Twenty-eight subjects with chronic atopic dermatitis received both terfenadine 120 mg b.d. and placebo each for a period of 1 week. Response was recorded by the subjects using visual analogue scales for severity of pruritus twice daily for the last 4 days of each treatment phase. There was no benefit from terfenadine.

Key concepts: Terfenadine, Atopic dermatitis, Placebo, Medicine, Dermatology, Allergy, Visual analogue scale, Anesthesia

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