2008•Mini-Reviews in Medicinal ChemistryRequires access

Nociceptin/Orphanin FQ Peptide Receptor as a Therapeutic Target for Obesity

Magdalena J. Przydzial, Lora K. Heisler

Abstract

Nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor is a candidate target for novel therapeutics for a range of conditions, including obesity. This article reviews recent advances in understanding of N/OFQs involvement in the regulation of food intake and appraises current developments in the rational design of antagonists aimed at the NOP receptor. Keywords: Nociceptin/orphanin FQ, N/OFQ, nociceptin/orphanin FQ peptide (NOP) receptor, opioid receptor like-1 (ORL-1), opioid receptor-4 (OP4), kappa-type 3 opioid receptor (KOR-3), rat opioid receptor-C (ROR-C), obesity, food intake

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Available abstract

Key concepts: Nociceptin receptor, Pharmacology, NOP, Receptor, Medicine, Peptide, Endocrinology, Chemistry