Cervical ripening and labor induction with 25 μg vs. 50 μg of intravaginal misoprostol

Various obstetrical and medical reasons necessitate induction of labor; its success depends mainly on the condition of the cervix. Misoprostol a synthetic prostaglandin E1 analog originally manufactured for prevention and treatment of peptic ulcer is as effective as dinoprostone for cervical ripening and labor induction; it costs much less than dinoprostone and does not require refrigeration. It can be applied with various routes and doses however 50 Ag or higher doses might be associated with a higher incidence of adverse effects. An open randomized controlled clinical trial was conducted at the labor ward ofWad Medani Hospital Sudan to test the efficacy of 25 Ag vs. 50 Ag intravaginal misoprostol for cervical ripening and labor induction. (excerpt)