1977•BJOG An International Journal of Obstetrics & GynaecologyRequires access

INCREASE OF THE PROSTAGLANDIN PRECURSOR, ARACHIDONIC ACID, IN AMNIOTIC FLUID DURING SPONTANEOUS LABOUR

Marc J. N. C. Keirse, B.R. Hicks, Murray David Mitchell, ALEXANDER C. TURNBULL

Abstract

Concentrations of free arachidonic acid have been measured by gas liquid chromatography in amniotic fluid obtained during spontaneous labour at term. Levels of arachidonic acid ranged from 0.14 to 2.9 microgram/ml and increased significantly (P less than 0.01) with advancing cervical dilatation. Concentrations of arachidonic acid showed no significant relation to concentrations of either prostaglandin F or 13,14-dihydro-15-keto-prostaglandin F. These findings are discussed with respect to the role of arachidonic acid in the control of prostaglandin biosynthesis during human parturition.

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Key concepts: Arachidonic acid, Prostaglandin, Amniotic fluid, Prostaglandins F, Chemistry, Internal medicine, Endocrinology, Biosynthesis