2013•Cancer Epidemiology Biomarkers & PreventionOpen access

Human Papillomavirus Infection and the Multistage Carcinogenesis of Cervical Cancer

Mark Schiffman, Nicolas Wentzensen

Abstract

Abstract This short review outlines our understanding of cervical cancer precursors, concentrating on the central etiologic role of persistent human papillomavirus infection. The stages of cervical carcinogenesis are better understood than for most other major cancers, providing a successful cancer etiology and prevention model. Cancer Epidemiol Biomarkers Prev; 22(4); 553–60. ©2013 AACR.

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Key concepts: Human papillomavirus, Cervical cancer, Carcinogenesis, Cancer, Virology, HPV infection, Medicine, Oncology