Pulmonary Eosinophilic Granuloma: Electron Microscopic Detection of X-Bodies on Lung Lavage Cells and Transbronchoscopic Lung Biopsy in One Patient

Brief Reports1 February 1982Pulmonary Eosinophilic Granuloma: Electron Microscopic Detection of X-Bodies on Lung Lavage Cells and Transbronchoscopic Lung Biopsy in One PatientFREDRIC C. KULLBERG, M.D., AKIRA FUNAHASHI, M.D., KENNETH A. SIEGESMUND, Ph.D.FREDRIC C. KULLBERG, M.D.Search for more papers by this author, AKIRA FUNAHASHI, M.D.Search for more papers by this author, KENNETH A. SIEGESMUND, Ph.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-96-2-188 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEosinophilic granuloma is a granulomatous disorder of uncertain cause, manifested by reactive proliferation of histiocytes that may involve the lung either as part of disseminated disease or in a "primary" form, without evidence of other organ involvement (1, 2). The diagnosis of pulmonary eosinophilic granuloma usually requires open lung biopsy, with light microscopic demonstration of nodular, interstitial lung infiltration with histiocytes and eosinophils.Several authors have reported finding rodlike intracytoplasmic inclusion bodies within histiocytes on electron microscopy of open lung biopsy specimens from patients with pulmonary eosinophilic granuloma (2-5). These cytoplasmic structures, called "X-bodies," are believed to be a characteristic...References1. BICKERSBLECHNEREKMAN JHP. Pulmonary eosinophilic granuloma: its natural history and prognosis. Am Rev Respir Dis. 1962;85:211-9. MedlineGoogle Scholar2. SMITHMCCORMACKVAN ORDSTRANDMERCER MLHR. "Primary" pulmonary histiocytosis-X. Chest. 1974;65:176-80. CrossrefMedlineGoogle Scholar3. GRACEYDIVERTIEBROWN DMA. Primary pulmonary histiocytosis X: electron microscopic study in eight cases. Chest. 1971;59:5-9. CrossrefMedlineGoogle Scholar4. BASSETSOLERWYLLIEMAZINTURIAF FPFFJ. Langerhans' cells and lung interstitium. Ann NY Acad Sci. 1976;278:599-611. CrossrefMedlineGoogle Scholar5. BASSETCORRINSPENCER FBH. Pulmonary histiocytosis X. Am Rev Respir Dis. 1978; 118:811-20. MedlineGoogle Scholar6. BASSETSOLERJALRANDBIGNON FPMJ. Ultrastructural examination of broncho-alveolar lavage for diagnosis of pulmonary histiocytosis X: preliminary report on 4 cases. Thorax. 1977;32:303-6. CrossrefMedlineGoogle Scholar7. BIRBECKBREATHNACHEVERALL MAJ. An electron microscope study of basal melanocytes and high level clear cells (Langerhans cells) in vitiligo. J Invest Dermatol. 1961;37:51-63. CrossrefGoogle Scholar8. ZELICKSON A. The Langerhans' cell. J Invest Dermatol. 1965;44:201-12. CrossrefMedlineGoogle Scholar9. SHAMOTOKAPLANKATOH MCA. Langerhans' cell granules in human hyperplastic lymph nodes. Arch Pathol. 1971;92:46-52. MedlineGoogle Scholar10. KAWANAMIBASSETFERRANSSOLERCRYSTAL OFVPR. Pulmonary Langerhans' cells in patients with fibrotic lung disorders. Lab Invest. 1981;44:227-33. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: FREDRIC C. KULLBERG, M.D.; AKIRA FUNAHASHI, M.D.; KENNETH A. SIEGESMUND, Ph.D.Affiliations: Veterans Administration Medical Center Wood (Milwaukee), Wisconsin Medical College of Wisconsin Milwaukee, Wisconsin PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byOTHER SMOKING-AFFECTED PULMONARY DISEASESCigaret smoking and the lungImmunohistochemical Diagnosis of Pulmonary Eosinophilic Granuloma on Lung BiopsyCase 8-1986: Eosinophilic Granuloma of LungCase 8-1986Systemic diseases with bronchial manifestationsAn Introduction to the Interstitial Lung DiseasesThe Interstitial Lung DiseasesFlexible fiberoptic bronchoscopy 1 February 1982Volume 96, Issue 2Page: 188-189KeywordsBiopsyCellsElectron microscopyEosinophilsGranulomasHistiocytesLungsMetastasisPulmonary diseases ePublished: 1 December 2008 Issue Published: 1 February 1982 PDF downloadLoading ...