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STIMULATION OF INSULIN SECRETION BY GLUCAGON AND SECRETIN

T. Deckert

Open publisher page 31 citations

Abstract

ABSTRACT Intravenous injection of 1.0 mg glucagon brings about a marked increase in the serum concentration of insulin in normal subjects. This increase sets in before the increase in blood sugar and reaches a peak 2–8 minutes after the injection. Intravenous injection of 75 units secretin also results in a rapid increase in the serum concentration of insulin in normal subjects. This increase is less marked than that following glucagon and reaches its peak 3–4 minutes after the injection. It must be assumed that glucagon as well as secretin contribute to the pronounced increase in insulin concentration during oral administration of glucose.

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What this paper is about

ABSTRACT Intravenous injection of 1.0 mg glucagon brings about a marked increase in the serum concentration of insulin in normal subjects. This increase sets in before the increase in blood sugar and reaches a peak 2–8 minutes after the injection. Intravenous injection of 75 units secretin also results in a rapid increase in the serum concentration of insulin in normal subjects. This increase is less marked than that following glucagon and reaches its peak 3–4 minutes after the injection. It must be assumed that glucagon as well as secretin contribute to the pronounced increase in insulin concentration during oral administration of glucose.

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Available abstract

ABSTRACT Intravenous injection of 1.0 mg glucagon brings about a marked increase in the serum concentration of insulin in normal subjects. This increase sets in before the increase in blood sugar and reaches a peak 2–8 minutes after the injection. Intravenous injection of 75 units secretin also results in a rapid increase in the serum concentration of insulin in normal subjects. This increase is less marked than that following glucagon and reaches its peak 3–4 minutes after the injection. It must be assumed that glucagon as well as secretin contribute to the pronounced increase in insulin concentration during oral administration of glucose.

Key concepts: Secretin, Internal medicine, Glucagon, Endocrinology, Insulin, Stimulation, Medicine, Blood sugar

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