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1995•The Journal of UrologyRequires access

Papaverine-Phentolamine and Prostaglandin E1 Versus Papaverine-Phentolamine Alone For Intracorporeal Injection Therapy: A Clinical Double-Blind Study

Ofer Z. Shenfeld, Jacob I. Hanani, Arieh L. Shalhav, Yoram Vardi, Benad Goldwasser

Open publisher page 35 citations

Abstract

PURPOSE: A study was designed to compare intracorporeal injections of papaverine plus phentolamine (2-drug solution) and papaverine plus phentolamine and prostaglandin E1 (3-drug solution) for the treatment for impotence. MATERIALS AND METHODS: A total of 20 impotent patients received intracorporeal injections of the 2-drug or 3-drug solution alternately during 2 sessions, and the quality and duration of erections were assessed. RESULTS: Of the patients 73% achieved a full erection with the 3-drug solution compared to 28% with the 2-drug solution. The average duration of erections was 57 minutes and 33.6 minutes, respectively. The complication rate was similar for the 2 treatments. CONCLUSIONS: Papaverine plus phentolamine and prostaglandin E1 is superior to papaverine plus phentolamine alone for the treatment of impotence.

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What this paper is about

PURPOSE: A study was designed to compare intracorporeal injections of papaverine plus phentolamine (2-drug solution) and papaverine plus phentolamine and prostaglandin E1 (3-drug solution) for the treatment for impotence. MATERIALS AND METHODS: A total of 20 impotent patients received intracorporeal injections of the 2-drug or 3-drug solution alternately during 2 sessions, and the quality and duration of erections were assessed. RESULTS: Of the patients 73% achieved a full erection with the 3-drug solution compared to 28% with the 2-drug solution. The average duration of erections was 57 minutes and 33.6 minutes, respectively. The complication rate was similar for the 2 treatments. CONCLUSIONS: Papaverine plus phentolamine and prostaglandin E1 is superior to papaverine plus phentolamine alone for the treatment of impotence.

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Available abstract

PURPOSE: A study was designed to compare intracorporeal injections of papaverine plus phentolamine (2-drug solution) and papaverine plus phentolamine and prostaglandin E1 (3-drug solution) for the treatment for impotence. MATERIALS AND METHODS: A total of 20 impotent patients received intracorporeal injections of the 2-drug or 3-drug solution alternately during 2 sessions, and the quality and duration of erections were assessed. RESULTS: Of the patients 73% achieved a full erection with the 3-drug solution compared to 28% with the 2-drug solution. The average duration of erections was 57 minutes and 33.6 minutes, respectively. The complication rate was similar for the 2 treatments. CONCLUSIONS: Papaverine plus phentolamine and prostaglandin E1 is superior to papaverine plus phentolamine alone for the treatment of impotence.

Key concepts: Phentolamine, Papaverine, Medicine, Prostaglandin E1, Urology, Blockade, Anesthesia, Surgery

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Papaverine-Phentolamine and Prostaglandin E1 Versus Papaverine-Phentolamine Alone For Intracorporeal Injection Therapy: A Clinical Double-Blind Study — Research Paper | ScholarLens