1976•Antimicrobial Agents and ChemotherapyOpen access

Absence of Penicillin-Degrading Enzymes in Penicillin-Resistant Strains of Neisseria gonorrhoeae

James L. Beebe, P. Ligeti, T. J. Wlodkowski

Abstract

Penicillin-resistant and -susceptible strains of Neisseria gonorrhoeae were evaluated for the presence of enzymes capable of degrading penicillin by incubation of [(14)C]benzylpenicillin with resting-cell suspensions of N. gonorrhoeae followed by extraction and chromatography of the labeled antibiotic. No degradative activity was observed.

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Key concepts: Neisseria gonorrhoeae, Penicillin, Benzylpenicillin, Microbiology, Incubation, Neisseria, Enzyme, Antibiotics