2011•Chemical CommunicationsRequires access
Heavily fluorinated carbohydrates as enzyme substrates: oxidation of tetrafluorinated galactose by galactose oxidase
Avgousta Ioannou, Elena Cini, Roxana S. Timofte, Sabine Lahja Flitsch, Nicholas J. Turner, Bruno Linclau
Open publisher page 34 citations
Abstract
Galactose oxidase (GOase) was shown to oxidise several C2/C3 fluorinated galactose analogues. Interestingly, the enzyme was able to distinguish between the 2,3-tetrafluorinated galactose and its epimeric glucose analogue, and this represents the first reported biotransformation of a heavily fluorinated sugar.