2012•Bioorganic & Medicinal ChemistryRequires access

Design, synthesis and preliminary bioactivity studies of 1,3,4-thiadiazole hydroxamic acid derivatives as novel histone deacetylase inhibitors

Peng Guan, Feng’e Sun, Xuben Hou, Feng Wang, Fan Yi, Wenfang Xu, Hao Fang

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Key concepts: Histone deacetylase, Hydroxamic acid, Chemistry, IC50, Apoptosis, Enzyme, Biochemistry, Cell growth

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Design, synthesis and preliminary bioactivity studies of 1,3,4-thiadiazole hydroxamic acid derivatives as novel histone deacetylase inhibitors — Research Paper | ScholarLens