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2011•JAIDS Journal of Acquired Immune Deficiency SyndromesRequires access

Prevalence of Etravirine-Associated Mutations in Clinical Samples With Genotypic Resistance to Nevirapine and Efavirenz in Brazilian Clinics

Angélica N. Martins, Mônica Arruda, Agdemir Waléria Aleixo, Ana Flávia Pires, Dirceu Bartolomeu Greco, Rodrigo de Moares Brindeiro, Amílcar Tanuri

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Abstract

Nonnucleoside reverse transcriptase inhibitors (NNRTIs) are potent and well tolerated. In Brazil, the first-generation NNRTI efavirenz is included in the majority of first-line antiretroviral treatment regimens. In this study, we evaluated the effectiveness of etravirine, a new second-generation NNRTI, among patients failing antiretroviral regimens containing first-generation NNRTIs. We assessed single resistance mutations to etravirine as well as complex resistance mutations profile and discuss the potential of introducing etravirine as salvage therapy.

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What this paper is about

Nonnucleoside reverse transcriptase inhibitors (NNRTIs) are potent and well tolerated. In Brazil, the first-generation NNRTI efavirenz is included in the majority of first-line antiretroviral treatment regimens. In this study, we evaluated the effectiveness of etravirine, a new second-generation NNRTI, among patients failing antiretroviral regimens containing first-generation NNRTIs. We assessed single resistance mutations to etravirine as well as complex resistance mutations profile and discuss the potential of introducing etravirine as salvage therapy.

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OpenAlex reports 3 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Nonnucleoside reverse transcriptase inhibitors (NNRTIs) are potent and well tolerated. In Brazil, the first-generation NNRTI efavirenz is included in the majority of first-line antiretroviral treatment regimens. In this study, we evaluated the effectiveness of etravirine, a new second-generation NNRTI, among patients failing antiretroviral regimens containing first-generation NNRTIs. We assessed single resistance mutations to etravirine as well as complex resistance mutations profile and discuss the potential of introducing etravirine as salvage therapy.

Key concepts: Etravirine, Efavirenz, Nevirapine, Reverse-transcriptase inhibitor, Virology, Medicine, Salvage therapy, Human immunodeficiency virus (HIV)

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Prevalence of Etravirine-Associated Mutations in Clinical Samples With Genotypic Resistance to Nevirapine and Efavirenz in Brazilian Clinics — Research Paper | ScholarLens