1970•British Journal of PharmacologyOpen access

Gastrin derivatives investigated for secretory potency and for changes in gastric mucosal histamine formation

Elsa Rosengren, Sören Svensson

Abstract

1. Acid secretion and rate of histamine formation in the gastric mucosa were determined in rats after injection of hog gastrin II, gastrin pentapeptide and some substituted analogues of the C-terminal tetrapeptide of gastrin.2. Accelerated mucosal histamine formation was induced by hog gastrin II, gastrin pentapeptide and those analogues which elicited acid secretion, whereas secretorily inactive derivatives did not alter histamine formation.

Open-access reader

About this research paper

What this paper is about

Why it matters

OpenAlex reports 2 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Gastrin, Histamine, Pentapeptide repeat, Tetrapeptide, Secretion, Internal medicine, G cell, Gastric acid