1979•Clinical ToxicologyRequires access

Comparison of the Cardiovascular Toxicity of Three Tricyclic Antidepressent Drugs: Imipramine, Amitriptyline, and Doxepin

T. C. K. Brown, A. Leversha

Abstract

Experiments were conducted on puppies to compare the cardiovascular toxicity of imipramine, amitriptyline, and doxepin. The drugs were infused at weekly intervals to produce arrhythmias and/or hypotension. Imipramine was less arrhythmogenic and caused less fall in blood pressure for a given dose than amitriptyline or doxepin.

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Key concepts: Doxepin, Amitriptyline, Imipramine, Tricyclic, Medicine, Pharmacology, Blood pressure, Toxicity