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2010•OphthalmologicaRequires access

Glycosaminoglycans of Trabecular Meshwork and Adjacent Tissues of the Rabbit Eye

Keizo Nishiyama

Open publisher page 2 citations

Abstract

Glycosaminoglycans (GAGs) extracted from the trabecular meshwork (TM) of rabbit eyes were analyzed by cellulose acetate electrophoresis and sequential enzymatic degradation, and compared with GAGs extracted from the adjacent tissues including the cornea, sclera, iris and ciliary body. The TM contained hyaluronic acid (HA), chondroitin 4- and/or 6-sulfate (CS), dermatan sulfate (DS), keratan sulfate (KS), heparan sulfate (HS) and an unidentified band of Alcian-blue-stained material which was resistant to degradation by the enzymes and chemicals used. The GAGs of the rabbit TM included: 13.9% HA, 31.6% CS, 47.1% DS, 4.6% KS and 1.2% HS, and were distinct from those of the cornea and the sclera.

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What this paper is about

Glycosaminoglycans (GAGs) extracted from the trabecular meshwork (TM) of rabbit eyes were analyzed by cellulose acetate electrophoresis and sequential enzymatic degradation, and compared with GAGs extracted from the adjacent tissues including the cornea, sclera, iris and ciliary body. The TM contained hyaluronic acid (HA), chondroitin 4- and/or 6-sulfate (CS), dermatan sulfate (DS), keratan sulfate (KS), heparan sulfate (HS) and an unidentified band of Alcian-blue-stained material which was resistant to degradation by the enzymes and chemicals used. The GAGs of the rabbit TM included: 13.9% HA, 31.6% CS, 47.1% DS, 4.6% KS and 1.2% HS, and were distinct from those of the cornea and the sclera.

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Available abstract

Glycosaminoglycans (GAGs) extracted from the trabecular meshwork (TM) of rabbit eyes were analyzed by cellulose acetate electrophoresis and sequential enzymatic degradation, and compared with GAGs extracted from the adjacent tissues including the cornea, sclera, iris and ciliary body. The TM contained hyaluronic acid (HA), chondroitin 4- and/or 6-sulfate (CS), dermatan sulfate (DS), keratan sulfate (KS), heparan sulfate (HS) and an unidentified band of Alcian-blue-stained material which was resistant to degradation by the enzymes and chemicals used. The GAGs of the rabbit TM included: 13.9% HA, 31.6% CS, 47.1% DS, 4.6% KS and 1.2% HS, and were distinct from those of the cornea and the sclera.

Key concepts: Keratan sulfate, Glycosaminoglycan, Sclera, Trabecular meshwork, Dermatan sulfate, Cornea, Hyaluronic acid, Chemistry

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