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BLOCKADE OF THE CENTRAL HYPOTENSIVE EFFECT OF CLONIDINE BY ?-ADRENORECEPTOR ANTAGONISTS IN RATS, RABBITS AND DOGS

Dominique Bogaievsky, Yvan Bogaievsky, Danita Tsoucaris‐Kupfer, Henri Schmitt

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Abstract

SUMMARY 1. Clonidine and three α-adrenoreceptor blocking agents were injected into the cisterna magna of rats, rabbits and dogs. Clonidine (1 μg. kg−1) induced a fall in blood pressure in the three species. 2. Phentolamine, tolazoline and phenoxybenzamine (100 μg. kg−1) induced a fall in blood pressure in rats, but only phentolamine was effective in rabbits, and none of these drugs significantly altered blood pressure in dogs when given intracisternally. 3. A subsequent administration of clonidine after recovery of blood pressure no longer decreased blood pressure in rats and rabbits. 4. In dogs the effects of clonidine were antagonized by tolazoline and phentolamine, but not by phenoxybenzamine. 5. These results indicate that clonidine stimulates central α-adrenoreceptors to produce a decrease in blood pressure, but the structure of these receptors may vary according to animal species.

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SUMMARY 1. Clonidine and three α-adrenoreceptor blocking agents were injected into the cisterna magna of rats, rabbits and dogs. Clonidine (1 μg. kg−1) induced a fall in blood pressure in the three species. 2. Phentolamine, tolazoline and phenoxybenzamine (100 μg. kg−1) induced a fall in blood pressure in rats, but only phentolamine was effective in rabbits, and none of these drugs significantly altered blood pressure in dogs when given intracisternally. 3. A subsequent administration of clonidine after recovery of blood pressure no longer decreased blood pressure in rats and rabbits. 4. In dogs the effects of clonidine were antagonized by tolazoline and phentolamine, but not by phenoxybenzamine. 5. These results indicate that clonidine stimulates central α-adrenoreceptors to produce a decrease in blood pressure, but the structure of these receptors may vary according to animal species.

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Available abstract

SUMMARY 1. Clonidine and three α-adrenoreceptor blocking agents were injected into the cisterna magna of rats, rabbits and dogs. Clonidine (1 μg. kg−1) induced a fall in blood pressure in the three species. 2. Phentolamine, tolazoline and phenoxybenzamine (100 μg. kg−1) induced a fall in blood pressure in rats, but only phentolamine was effective in rabbits, and none of these drugs significantly altered blood pressure in dogs when given intracisternally. 3. A subsequent administration of clonidine after recovery of blood pressure no longer decreased blood pressure in rats and rabbits. 4. In dogs the effects of clonidine were antagonized by tolazoline and phentolamine, but not by phenoxybenzamine. 5. These results indicate that clonidine stimulates central α-adrenoreceptors to produce a decrease in blood pressure, but the structure of these receptors may vary according to animal species.

Key concepts: Clonidine, Phentolamine, Phenoxybenzamine, Tolazoline, Blood pressure, Propranolol, Endocrinology, Medicine

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BLOCKADE OF THE CENTRAL HYPOTENSIVE EFFECT OF CLONIDINE BY ?-ADRENORECEPTOR ANTAGONISTS IN RATS, RABBITS AND DOGS — Research Paper | ScholarLens