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[Cutaneous Histoplasmosis and AIDS].

Miguel Reyes, Luis Roberto Arenas, Patricia Pichardo, Rodolfo Vick, Alfredo Torres, Rogelio Zacarías

Open publisher page 13 citations

Abstract

Histoplasmosis is usually a lung infection due to Histoplasma capsulatum var Capsulatum. Skin lesions are present in 10 to 17% of cases and it appears to have higher prevalence in Mexico. We report on three cases, all males with AIDS, of 26, 33 and 44 years of age. They presented fever, lymphadenopathy and weight loss. One had lingual ulcer and the other two, disseminated erythemato-violaceus plaques, papular and fistular lesions. The histopathologic study showed granulomatous lesions and Histoplasma capsulatum was isolated in cultures. All patients were treated successfully with amphotericin B with a total of 1.5 gm accumulative dose. Clinical skin lesions of histoplasmosis and good response to treatment are discussed.

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What this paper is about

Histoplasmosis is usually a lung infection due to Histoplasma capsulatum var Capsulatum. Skin lesions are present in 10 to 17% of cases and it appears to have higher prevalence in Mexico. We report on three cases, all males with AIDS, of 26, 33 and 44 years of age. They presented fever, lymphadenopathy and weight loss. One had lingual ulcer and the other two, disseminated erythemato-violaceus plaques, papular and fistular lesions. The histopathologic study showed granulomatous lesions and Histoplasma capsulatum was isolated in cultures. All patients were treated successfully with amphotericin B with a total of 1.5 gm accumulative dose. Clinical skin lesions of histoplasmosis and good response to treatment are discussed.

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Available abstract

Histoplasmosis is usually a lung infection due to Histoplasma capsulatum var Capsulatum. Skin lesions are present in 10 to 17% of cases and it appears to have higher prevalence in Mexico. We report on three cases, all males with AIDS, of 26, 33 and 44 years of age. They presented fever, lymphadenopathy and weight loss. One had lingual ulcer and the other two, disseminated erythemato-violaceus plaques, papular and fistular lesions. The histopathologic study showed granulomatous lesions and Histoplasma capsulatum was isolated in cultures. All patients were treated successfully with amphotericin B with a total of 1.5 gm accumulative dose. Clinical skin lesions of histoplasmosis and good response to treatment are discussed.

Key concepts: Histoplasmosis, Histoplasma, Histoplasma capsulatum, Medicine, Amphotericin B, Dermatology, Skin lesion, Lung

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