1994•Journal of Medical PrimatologyRequires access

Inhibition of simian immunodeficiency virus (SIV) replication by CD8 + cells of SIV‐infected rhesus macaques: Implications for immunopathogenesis

David J. Blackbourn, Linda F. Chuang, Keith F. Killam, Ronald Y. Chuang

Abstract

The ability of the CD8+ cells from simian immunodeficiency virus (SIV)-infected rhesus macaques to inhibit SIV replication was investigated. Inhibition was produced by a heat-stable soluble factor of molecular size greater than 10kDa. CD8+ supernatants from some macaques were found not only to suppress SIV growth but also to be cytolytic toward both infected and uninfected CD4+ cells. Such indiscriminate CD8+ cell-mediated cell killing may therefore account for DC4+ cell depletion in certain SIV-infected macaques.

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Key concepts: Simian immunodeficiency virus, Virology, Viral replication, Biology, Rhesus macaque, Simian, CD8, Replication (statistics)