EXPERIMENTAL STUDY ON CONTACT DERMATITIS CAUSED BY FUNGICIDES BENOMYL AND THIOPHANATE-METHYL

Though primary irritancy was not indicated for fungicides benomyl and thiophanate-methyl, extreme potency of contact sensitization was estimated only for benomyl from the guinea pig maximization test. Allergenicity ratings of sulfuric compounds, lime sulfur mixture and wettable sulfur powder, and a portion of chemical structure for benomyl, i.e., n-butyl carbamate were noted to be moderate, but such degree of allergenicity was not observed in cases of thiophanate-methyl and one of their metabolite MBC. Contact sensitization for thiophanate-methyl, however, seemed to be potentiate slightly when used with a sulfuric compound. The cross sensitization between benomyl and thiophanate-methyl was not revealed.