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Deep Penetrating Dermatofibroma

CATHERINE L. LAUGHLIN, Patrick R. Carrington

Open publisher page 10 citations

Abstract

BACKGROUND: Deep penetrating dermatofibroma is an unusual and histologically distinctive form of dermatofibroma that usually occurs on the lower extremities of adults. OBJECTIVE: The dermatologic surgeon and pathologist should be aware of this entity to prevent excessive treatment of a benign condition. METHODS: We are reporting a case of deep penetrating dermatofibroma with the results of histologic examination and immunohistochemical studies. RESULTS: The neoplasm consisted of a fibrohistiocytic tumor penetrating into the subcutis accompanied by scalloped extensions along the septae. Immunohistochemical stains were positive for Factor XIIIa and negative for CD34. CONCLUSION: Recognition of the histologic pattern is important in distinguishing deep penetrating dermatofibroma from dermatofibrosarcoma protuberans.

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What this paper is about

BACKGROUND: Deep penetrating dermatofibroma is an unusual and histologically distinctive form of dermatofibroma that usually occurs on the lower extremities of adults. OBJECTIVE: The dermatologic surgeon and pathologist should be aware of this entity to prevent excessive treatment of a benign condition. METHODS: We are reporting a case of deep penetrating dermatofibroma with the results of histologic examination and immunohistochemical studies. RESULTS: The neoplasm consisted of a fibrohistiocytic tumor penetrating into the subcutis accompanied by scalloped extensions along the septae. Immunohistochemical stains were positive for Factor XIIIa and negative for CD34. CONCLUSION: Recognition of the histologic pattern is important in distinguishing deep penetrating dermatofibroma from dermatofibrosarcoma protuberans.

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Available abstract

BACKGROUND: Deep penetrating dermatofibroma is an unusual and histologically distinctive form of dermatofibroma that usually occurs on the lower extremities of adults. OBJECTIVE: The dermatologic surgeon and pathologist should be aware of this entity to prevent excessive treatment of a benign condition. METHODS: We are reporting a case of deep penetrating dermatofibroma with the results of histologic examination and immunohistochemical studies. RESULTS: The neoplasm consisted of a fibrohistiocytic tumor penetrating into the subcutis accompanied by scalloped extensions along the septae. Immunohistochemical stains were positive for Factor XIIIa and negative for CD34. CONCLUSION: Recognition of the histologic pattern is important in distinguishing deep penetrating dermatofibroma from dermatofibrosarcoma protuberans.

Key concepts: Dermatofibroma, Dermatofibrosarcoma protuberans, Medicine, Factor XIIIa, Dermatopathology, CD34, Pathology, Immunohistochemistry

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