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EVIDENCE FOR TWO SPECIES OF INSULIN-LIKE GROWTH FACTOR II (IGF II AND “BIG” IGF II) IN HUMAN SPINAL FLUID

Gisela K. Haselbacher, R Humbel

Open publisher page 160 citations

Abstract

Human serum contains the somatomedins, insulin-like growth factor I and II (IGF I and II). In spinal fluid, however, only IGF II was found in measurable and significant amounts. In addition, an IGF II of larger mass could be detected by a radioimmunoassay for IGF II. This "big" IGF II is biologically active and has an apparent molecular weight of 9000.

About this research paper

What this paper is about

Human serum contains the somatomedins, insulin-like growth factor I and II (IGF I and II). In spinal fluid, however, only IGF II was found in measurable and significant amounts. In addition, an IGF II of larger mass could be detected by a radioimmunoassay for IGF II. This "big" IGF II is biologically active and has an apparent molecular weight of 9000.

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OpenAlex reports 160 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Human serum contains the somatomedins, insulin-like growth factor I and II (IGF I and II). In spinal fluid, however, only IGF II was found in measurable and significant amounts. In addition, an IGF II of larger mass could be detected by a radioimmunoassay for IGF II. This "big" IGF II is biologically active and has an apparent molecular weight of 9000.

Key concepts: Endocrinology, Internal medicine, Insulin-like growth factor, Growth factor, Insulin, Somatomedin, Biology, Chemistry

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EVIDENCE FOR TWO SPECIES OF INSULIN-LIKE GROWTH FACTOR II (IGF II AND “BIG” IGF II) IN HUMAN SPINAL FLUID — Research Paper | ScholarLens