2006•Chemical CommunicationsRequires access

Alternative donor substrates for inverting and retaining glycosyltransferases

Luke L. Lairson, Warren W. Wakarchuk, Stephen G. Withers

Abstract

By the use of glycosyl donors containing aromatic leaving groups linked with opposite anomeric configurations compared to those of the natural donor substrates, an inverting (Cst II) and a retaining (LgtC) glycosyltransferase were found to catalyse glycosylation reactions of natural acceptor substrates in the presence of the corresponding nucleotide.

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Available abstract

Key concepts: Glycosyltransferase, Glycosyl donor, Glycosylation, Glycosyl, Anomer, Chemistry, Acceptor, Stereochemistry