1979•Microbiology and ImmunologyOpen access

Pathogenesis of Hobbs' Heat‐Sensitive Spore Forming Clostridium perfringens Type A Strain†

A. K. Chakrabarty, K. G. Narayan

Abstract

Food poisoning in man due to heat-sensitive strains of Cl. perfringens type A appeared to be mediated through enterotoxin synthesized in vivo during sporulation. A minimum of 2.0 X 10(5) vegetative cells suspended in sporulation medium was sufficient to elicit gut-loop response in rabbits. The functional disturbance in the gut as well as the structural changes were progressive and proportional to the size of the inoculum up to a dose limit of 2.0 X 10(7) vegetative cells and beyond this the changes remained steady.

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Key concepts: Clostridium perfringens, Spore, Biology, Microbiology, Enterotoxin, Strain (injury), Pathogenesis, In vivo