2013•Journal of Enzyme Inhibition and Medicinal ChemistryOpen access

Carbonic anhydrase inhibitory properties of novel sulfonamide derivatives of aminoindanes and aminotetralins

Yusuf Akbaba, Akın Akıncıoğlu, Hülya Göçer, Süleyman Göksu, İlhami Gülçın, Claudiu T. Supuran

Abstract

Six sulfonamides derived from indanes and tetralines were synthesized. The human carbonic anhydrase isozymes hCA I and hCA II inhibition effects of the synthesized sulfonamides were determined. From these compounds, while N-(5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methane sulfonamide showed the most potent inhibitory effect against hCA I (Ki=46 ± 5.4 µM, r(2) =0.978), N-(1,2,3,4-tetrahydronaphthalene-2-yl)methanesulfonamide was found to have the best inhibitory effect against hCA II (Ki=94 ± 7.6 µM, r(2) =0.982).

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Key concepts: Sulfonamide, Carbonic anhydrase, Chemistry, Carbonic Anhydrase I, Isozyme, Inhibitory postsynaptic potential, Enzyme inhibition, Enzyme