1998•Nature MedicineRequires access

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

Leigh A. Holcomb, Marcia N. Gordon, Eileen McGowan, Xin Yu, Stan Benkovic, Paul Jantzen, Kristal Wright, Irene Saad, Ryan Mueller, Dave Morgan, Sunny Sanders, Cindy Zehr, Kassandra O'Campo, John Hardy, Cristian-Mihail Prada, Chris Eckman, Steve Younkin, Karen Hsiao, Karen Duff

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Key concepts: Presenilin, Genetically modified mouse, Transgene, Mutant, Amyloid precursor protein, Mutation, Alzheimer's disease, Biology