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1961•New England Journal of MedicineRequires access

Tropical Sprue and Vitamin B12

Thomas W. Sheehy, Enrique Pérez-Santiago, Milton E. Rubini, F. E. Fradera

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Abstract

THE entire small intestine is involved in maintenance of normal erythropoiesis and in the prevention of megaloblastic anemia. The proximal small bowel is involved in absorption and maintenance of an adequate supply of folic acid,1 whereas the distal portion is essential for absorption of vitamin B12.2 , 3 Interference with absorption of either substance may lead to the development of megaloblastic anemia. Tropical sprue is one of many diseases in which abnormal intestinal function may precipitate anemia. Usually, this anemia has been attributed to a deficiency of folic acid, but sprue is a disease in which the entire small bowel . . .

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What this paper is about

THE entire small intestine is involved in maintenance of normal erythropoiesis and in the prevention of megaloblastic anemia. The proximal small bowel is involved in absorption and maintenance of an adequate supply of folic acid,1 whereas the distal portion is essential for absorption of vitamin B12.2 , 3 Interference with absorption of either substance may lead to the development of megaloblastic anemia. Tropical sprue is one of many diseases in which abnormal intestinal function may precipitate anemia. Usually, this anemia has been attributed to a deficiency of folic acid, but sprue is a disease in which the entire small bowel . . .

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Available abstract

THE entire small intestine is involved in maintenance of normal erythropoiesis and in the prevention of megaloblastic anemia. The proximal small bowel is involved in absorption and maintenance of an adequate supply of folic acid,1 whereas the distal portion is essential for absorption of vitamin B12.2 , 3 Interference with absorption of either substance may lead to the development of megaloblastic anemia. Tropical sprue is one of many diseases in which abnormal intestinal function may precipitate anemia. Usually, this anemia has been attributed to a deficiency of folic acid, but sprue is a disease in which the entire small bowel . . .

Key concepts: Megaloblastic anemia, Malabsorption, Tropical sprue, Vitamin B12, Medicine, Anemia, Sprue, Small intestine

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