Mitchell A. Avery, Jason D. Bonk, Sanjiv Mehrotra
Abstract
The stereoselective total synthesis of the antimalarial agents artemisinin-d3 (1), dihydroartemisinin-d3 (2), and arteether-d3 (3), incorporating 2H at C-16 (C-9 methyl) is reported.
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The stereoselective total synthesis of the antimalarial agents artemisinin-d3 (1), dihydroartemisinin-d3 (2), and arteether-d3 (3), incorporating 2H at C-16 (C-9 methyl) is reported.
Key concepts: Dihydroartemisinin, Artemisinin, Chemistry, Stereoselectivity, Stereochemistry, Pharmacology, Combinatorial chemistry, Plasmodium falciparum