2008•Journal of the American Chemical SocietyOpen access

pH Controlled Release of Chromone from Chromone-Fe3O4 Nanoparticles

Baodui Wang, Chenjie Xu, Jin Xie, Zheng‐yin Yang, Shouheng Sun

Abstract

We report a new strategy for coupling chromone to Fe3O4 nanoparticles. The chromone-Fe3O4 NP conjugate shows a dramatic increase in chromone solubility in cell culture medium from less than 2.5 to 633 microg/ml, leading to the enhanced chromone uptake by HeLa cells. Chromone can be released at low pH and as a result, the chromone-Fe3O4 conjugate is much more efficient in inhibiting the HeLa cell proliferation. Such chromone-Fe3O4 NPs are promising as a powerful multifunctional delivery system for both chromone-based diagnostic and therapeutic applications.

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Key concepts: Chromone, Chemistry, HeLa, Conjugate, Nanoparticle, Solubility, Combinatorial chemistry, Stereochemistry