2010•The Anatomical RecordOpen access

Neurogenesis in the Adult Goldfish Cerebellum

Luz Delgado, Oliver Schmachtenberg

Abstract

Neurogenesis was studied in the cerebellum of adult goldfish, to establish the phenomenon in this popular laboratory animal model. BrdU and proliferating cell nuclear antigen labeling revealed a high rate of cell proliferation within the molecular layer of the cerebellar corpus and valve. Most newborn cells expressed the neuronal marker beta-III-tubulin after 24 hr, supporting the goldfish cerebellum as an excellent paradigm to study vertebrate adult neurogenesis.

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Key concepts: Neurogenesis, Cerebellum, Neuroscience, Biology, Vertebrate, Purkinje cell, Gene, Genetics