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HAEMOPHILUS INFLUENZAE TYPE B IN ACUTE LARYNGITIS WITH BACTEREMIA

SYDNEY E. SINCLAIR

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Abstract

Pittman1in 1931 demonstrated that the invasive strains of Haemophilus influenzae, in contradistinction to the strains ordinarily found in the nasopharynx, possess a capsule. The capsule contains a soluble substance which reacts with the homologous immune serum, and on the basis of this reaction six serologic types of H. influenzae (A through F) have been described. Of the organisms recovered in cases of influenzal meningitis, 92 to 95 per cent2have been type B. Recovery of type B organisms from sources other than the meninges has been unusual. The purpose of this communication is to describe 10 instances in which H. influenzae type B was found in cultures of the blood taken from patients desperately ill with acute laryngitis. Special interest attaches to the fact that 8 of these cases occurred within the fifteen month period from Jan. 1, 1940 to April 1, 1941, whereas the other 2

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What this paper is about

Pittman1in 1931 demonstrated that the invasive strains of Haemophilus influenzae, in contradistinction to the strains ordinarily found in the nasopharynx, possess a capsule. The capsule contains a soluble substance which reacts with the homologous immune serum, and on the basis of this reaction six serologic types of H. influenzae (A through F) have been described. Of the organisms recovered in cases of influenzal meningitis, 92 to 95 per cent2have been type B. Recovery of type B organisms from sources other than the meninges has been unusual. The purpose of this communication is to describe 10 instances in which H. influenzae type B was found in cultures of the blood taken from patients desperately ill with acute laryngitis. Special interest attaches to the fact that 8 of these cases occurred within the fifteen month period from Jan. 1, 1940 to April 1, 1941, whereas the other 2

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OpenAlex reports 110 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

Pittman1in 1931 demonstrated that the invasive strains of Haemophilus influenzae, in contradistinction to the strains ordinarily found in the nasopharynx, possess a capsule. The capsule contains a soluble substance which reacts with the homologous immune serum, and on the basis of this reaction six serologic types of H. influenzae (A through F) have been described. Of the organisms recovered in cases of influenzal meningitis, 92 to 95 per cent2have been type B. Recovery of type B organisms from sources other than the meninges has been unusual. The purpose of this communication is to describe 10 instances in which H. influenzae type B was found in cultures of the blood taken from patients desperately ill with acute laryngitis. Special interest attaches to the fact that 8 of these cases occurred within the fifteen month period from Jan. 1, 1940 to April 1, 1941, whereas the other 2

Key concepts: Medicine, Haemophilus influenzae, Bacteremia, Meningitis, Microbiology, Laryngitis, Capsule, Serology

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