IgG Subclass Defficiency and Its Relation to IgA Deficiency

Abstract Children may suffer from deficiency of one or more of the IgG subclasses‐ although the total level of IgG may be normal‐resulting in recurrent bacterial infections. Subclass deficiency may also be seen in some other well‐defined immuno deficiency states, i. a. selective IgA deficiency. Thus, IgG2 deficiency was found in 5 of 22 such children with symptoms of various diseases. Normal IgG2 levels were found in sera from 11 healthy individuals with selective IgA deficiency. IgGl levels of the whole IgA deficient group were significantly increased as compared to a normal reference group.