Synthesis of Uridylyl (3′-5′) Uridine Derivatives Containing 5-(Methylamino-Methyl) Uridine as A Modified Nucleoside Found fromE. COLIMinor tRNAArg
Mitsuo Sekine, Kohji Seio, Takahiko Satoh, Kensaku Sakamoto, Shigeyuki Yokoyama
Abstract
Mitsuo Sekine, Kohji Seio, Takahiko Satoh, Kensaku Sakamoto, Shigeyuki Yokoyama
Abstract
5-(Methylaminomethyl)uridine-containing uridylyl (3′-5′) uridine derivatives (14, 26, and 29), which were the original and modified sequences corresponding to the first letter (position 34) and the 5′-upper ribonucleoside (position 33) in the anticodon loop of minor tRNAArg, have been synthesized via 5-(methylaminomethyl)uridine derivatives (4 and 24).
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5-(Methylaminomethyl)uridine-containing uridylyl (3′-5′) uridine derivatives (14, 26, and 29), which were the original and modified sequences corresponding to the first letter (position 34) and the 5′-upper ribonucleoside (position 33) in the anticodon loop of minor tRNAArg, have been synthesized via 5-(methylaminomethyl)uridine derivatives (4 and 24).
Key concepts: Uridine, Ribonucleoside, Transfer RNA, Nucleoside, Chemistry, Stereochemistry, RNA, Biochemistry