2003The Journal of Cell BiologyOpen access

Binding takes cooperation

Nicole D. LeBrasseur

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Abstract

![][1] The odds of binding rise rapidly with more binding sites. Klein/Elsevier The CDK inhibitor Sic1 gets proteolyzed in late G1, but the regulation of its binding to the Cdc4 ubiquitin ligase subunit has been a conundrum. The proteins do not bind unless Sic1 is phosphorylated on

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![][1] The odds of binding rise rapidly with more binding sites. Klein/Elsevier The CDK inhibitor Sic1 gets proteolyzed in late G1, but the regulation of its binding to the Cdc4 ubiquitin ligase subunit has been a conundrum. The proteins do not bind unless Sic1 is phosphorylated on

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Available abstract

![][1] The odds of binding rise rapidly with more binding sites. Klein/Elsevier The CDK inhibitor Sic1 gets proteolyzed in late G1, but the regulation of its binding to the Cdc4 ubiquitin ligase subunit has been a conundrum. The proteins do not bind unless Sic1 is phosphorylated on

Key concepts: Biology, Ubiquitin ligase, Plasma protein binding, DNA-binding protein, Binding site, Ubiquitin-Protein Ligases, Protein subunit, Cell biology

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