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Does B cell depletion have a role to play in the treatment of systemic lupus erythematosus?

C Gorman, Maria Leandro, David Isenberg

Open publisher page 17 citations

Abstract

B cell dysfunction and pathogenic autoantibody formation are thought to be critical in the pathogenesis of systemic lupus erythematosus (SLE). In this review we will summarize the results of attempts to utilize B cell depletion, based on the use of a chimeric monoclonal antibody (MAb) specific for human CD20, rituximab, for the treatment of patients with SLE.

About this research paper

What this paper is about

B cell dysfunction and pathogenic autoantibody formation are thought to be critical in the pathogenesis of systemic lupus erythematosus (SLE). In this review we will summarize the results of attempts to utilize B cell depletion, based on the use of a chimeric monoclonal antibody (MAb) specific for human CD20, rituximab, for the treatment of patients with SLE.

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OpenAlex reports 17 citations for this work. Citation counts describe recorded attention and do not establish research quality.

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Available abstract

B cell dysfunction and pathogenic autoantibody formation are thought to be critical in the pathogenesis of systemic lupus erythematosus (SLE). In this review we will summarize the results of attempts to utilize B cell depletion, based on the use of a chimeric monoclonal antibody (MAb) specific for human CD20, rituximab, for the treatment of patients with SLE.

Key concepts: Medicine, Rituximab, Autoantibody, Pathogenesis, CD20, Immunology, Monoclonal antibody, Monoclonal

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Does B cell depletion have a role to play in the treatment of systemic lupus erythematosus? — Research Paper | ScholarLens