IgG Paraproteinemia Associated With Bronchogenic Carcinoma

The PRESENCE of excessive amounts of serum globulins in association with various types of disease processes, including neoplasia, is well recognized.1In some instances these paraproteins behave as macroglobulins,2cryoglobulins,3pyroglobulins4or are altered in some other manner chemically, immunologically, or electrophoretically. When the presence of a narrow, homogeneous globulin band on serum protein electrophoresis is discovered, multiple myeloma, less frequently macroglobulinemia or cryoglobulinemia, is considered the most likely diagnostic possibility. However, the occurrence of an identical pattern is recognized in association with various types of malignant lymphomas and leukemias.5Occasionally this narrow, discrete, homogeneous band appears in association with malignant neoplasms of epithelial cell origin.6The purpose of this paper is to describe the occurrence of an IgG paraproteinemia in association with bronchogenic carcinoma. Report of a Case A 65-year-old Negro man was admitted to Charity Hospital of Louisiana in New Orleans on April 7, 1965, because of progressive