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Novel Poly(Ester Amine) Based on Polycaprolactone and Polyethylenimine as a Gene Carrier: Effect of Hydrophobicity on Transfection Efficiency and Cytotoxicity

Rohidas B. Arote, Tae Hee Kim, You Kyoung Kim, Dhananjay Jere, Hu Lin Jiang, In Young Park, Myung‐Haing Cho, Jae Woon Nah, Chong Su Cho

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Abstract

Novel, biodegradable poly(ester amine)s (PEAs) were synthesized using hydrophobic polycaprolactone diacrylate (PCLDA) and highly cationic polyethylenimine (PEI). This novel gene carrier can form stable DNA complexes with particle sizes around 200 nm, and showing excellent transfection efficiency and relatively low cytotoxicity compared with PEI 25K. Effect of hydrophobicity on transfection efficiency and cytotoxicity was profound and was relatively important parameter for the success of gene delivery.

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Key concepts: Polyethylenimine, Polycaprolactone, Cytotoxicity, Transfection, Gene delivery, Cationic polymerization, Amine gas treating, Materials science