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2010•Clinical and Vaccine ImmunologyOpen access

Persistence of Leishmania donovani Antibodies in Past Visceral Leishmaniasis Cases in India

Kamlesh Gidwani, Albert Picado, Bart Ostyn, Shri Prakash Singh, Rajiv Kumar, Basudha Khanal, Veerle Lejon, François Chappuis, Marleen Boelaert, Shyam Sundar

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Abstract

The persistence of anti-Leishmania donovani antibodies in past visceral leishmaniasis (VL) cases was retrospectively assessed by means of the direct agglutination test (DAT) and the rK39 enzyme-linked immunosorbent assay (ELISA). Antibody titers remained high for an extended period of time in past cases of VL. These results highlight the need to carefully elicit the history of patients with VL symptoms.

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The persistence of anti-Leishmania donovani antibodies in past visceral leishmaniasis (VL) cases was retrospectively assessed by means of the direct agglutination test (DAT) and the rK39 enzyme-linked immunosorbent assay (ELISA). Antibody titers remained high for an extended period of time in past cases of VL. These results highlight the need to carefully elicit the history of patients with VL symptoms.

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Available abstract

The persistence of anti-Leishmania donovani antibodies in past visceral leishmaniasis (VL) cases was retrospectively assessed by means of the direct agglutination test (DAT) and the rK39 enzyme-linked immunosorbent assay (ELISA). Antibody titers remained high for an extended period of time in past cases of VL. These results highlight the need to carefully elicit the history of patients with VL symptoms.

Key concepts: Leishmania donovani, Visceral leishmaniasis, Direct agglutination test, Persistence (discontinuity), Leishmaniasis, Antibody, Titer, Immunology

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