2012•Clinical NephrologyRequires access

Rapidly progressive glomerulonephritis due to anti-glomerular basement membrane disease accompanied by IgA nephropathy: a case report

Bixia Gao, Mingxi Li, Wenli Xia, Yubin Wen, Zhen Qu

Abstract

Anti-glomerular basement membrane (anti-GBM) disease is characterized by autoantibodies against antigenic site on type IV collagen of the GBM. The coexistence of anti-GBM disease and other immune complex mediated glomerulonephritis is common. Herein, we describe a patient presented with rapidly progressive glomerulonephritis, who was diagnosed as IgA-mediated nephropathy and was found to have abundant serum anti-glomerular basement membrane IgG antibodies. The patient's renal function improved considerably with intensive immunosuppressive therapy.

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Key concepts: Medicine, Glomerulonephritis, Glomerular basement membrane, Rapidly progressive glomerulonephritis, Basement membrane, Nephropathy, Autoantibody, Immunology