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Renal 131I-hippuran extraction in man: effects of dopamine.

Martin Hutchings, Birger Hesse, Jenny L.E. Grönvall, Niels Vidiendal Olsen

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Abstract

AIMS: This study examined the 131I-hippuran extraction fraction during baseline renal blood flow rates and at high flow rates induced by dopamine. METHODS: In 12 healthy subjects, arterial and renal venous sampling was used to measure the renal extraction of 131I-hippuran. Effective renal plasma flow values determined by the urinary clearance of 131I-hippuran were compared with renal plasma flow values corrected for incomplete extraction of 131I-hippuran. RESULTS: Dopamine (3 micro g kg-1 min-1) decreased 131I-hippuran extraction from 75 +/- 4% at baseline to 62 +/- 6% (means +/- 95% confidence intervals, P < 0.001). Hence, the increase in renal plasma flow (85 +/- 23%) greatly exceeded the rise in effective renal plasma flow (51 +/- 15%, P < 0.002). CONCLUSIONS: Dopamine induced increases in renal blood flow are largely under-estimated when measurements are not corrected for incomplete extraction of 131I-hippuran.

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AIMS: This study examined the 131I-hippuran extraction fraction during baseline renal blood flow rates and at high flow rates induced by dopamine. METHODS: In 12 healthy subjects, arterial and renal venous sampling was used to measure the renal extraction of 131I-hippuran. Effective renal plasma flow values determined by the urinary clearance of 131I-hippuran were compared with renal plasma flow values corrected for incomplete extraction of 131I-hippuran. RESULTS: Dopamine (3 micro g kg-1 min-1) decreased 131I-hippuran extraction from 75 +/- 4% at baseline to 62 +/- 6% (means +/- 95% confidence intervals, P < 0.001). Hence, the increase in renal plasma flow (85 +/- 23%) greatly exceeded the rise in effective renal plasma flow (51 +/- 15%, P < 0.002). CONCLUSIONS: Dopamine induced increases in renal blood flow are largely under-estimated when measurements are not corrected for incomplete extraction of 131I-hippuran.

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Available abstract

AIMS: This study examined the 131I-hippuran extraction fraction during baseline renal blood flow rates and at high flow rates induced by dopamine. METHODS: In 12 healthy subjects, arterial and renal venous sampling was used to measure the renal extraction of 131I-hippuran. Effective renal plasma flow values determined by the urinary clearance of 131I-hippuran were compared with renal plasma flow values corrected for incomplete extraction of 131I-hippuran. RESULTS: Dopamine (3 micro g kg-1 min-1) decreased 131I-hippuran extraction from 75 +/- 4% at baseline to 62 +/- 6% (means +/- 95% confidence intervals, P < 0.001). Hence, the increase in renal plasma flow (85 +/- 23%) greatly exceeded the rise in effective renal plasma flow (51 +/- 15%, P < 0.002). CONCLUSIONS: Dopamine induced increases in renal blood flow are largely under-estimated when measurements are not corrected for incomplete extraction of 131I-hippuran.

Key concepts: Extraction ratio, Renal blood flow, Effective renal plasma flow, PAH clearance, Urology, Blood flow, Confidence interval, Internal medicine

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