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2006•Bioorganic & Medicinal Chemistry LettersOpen access

Structure-based drug design of a highly potent CDK1,2,4,6 inhibitor with novel macrocyclic quinoxalin-2-one structure

Nobuhiko Kawanishi, T Sugimoto, Jun Shibata, Kaori Nakamura, Kouta Masutani, Mari Ikuta, Hiroshi Hirai

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Key concepts: Chemistry, Cyclin-dependent kinase 1, Cyclin-dependent kinase, CDK inhibitor, Quinoxaline, Stereochemistry, Drug, In vivo

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Structure-based drug design of a highly potent CDK1,2,4,6 inhibitor with novel macrocyclic quinoxalin-2-one structure — Research Paper | ScholarLens